Use Caution/Monitor. Monitor Closely (1)tacrolimus and citalopram both increase QTc interval. Avoid or Use Alternate Drug. pharmacodynamic synergism. Modify Therapy/Monitor Closely. Use Caution/Monitor. health information, we will treat all of that information as protected health Either increases toxicity of the other by serotonin levels. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. If possible, avoid concurrent use. citalopram, aspirin/citric acid/sodium bicarbonate. lopinavir increases levels of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of bipolar/manic-depressive disorder, personal or family history of suicide attempts, liver disease, seizures, low sodium in the blood, bleeding problems, personal or family history of glaucoma (angle-closure type).Citalopram may cause a condition that affects the heart rhythm (QT prolongation). Monitor Closely (1)lapatinib and citalopram both increase QTc interval. Use Caution/Monitor. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Increased risk of upper GI bleeding. ECG monitoring is recommended, along with drugs that may prolong the QT interval. Serious - Use Alternative (2)citalopram and amitriptyline both increase serotonin levels. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and reduces efficacy related to these substrates. Avoid or Use Alternate Drug. If possible, avoid concurrent use. Use Caution/Monitor. Encorafenib is associated with dose-dependent QTc interval prolongation. Monitor Closely (1)citalopram, betrixaban. This drug should be taken as a single daily dose in the morning or evening; the dose may be taken without regard to meals. Use Caution/Monitor. Keep all medical and lab appointments. If possible, avoid concurrent use. The following information includes only the average doses of this medicine. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Drug information provided by: Merative, Micromedex. Increases risk of torsades de pointes. If you are taking citalopram to prevent panic attacks, your starting dose will usually be 10mg once a day. Modify Therapy/Monitor Closely. ECG monitoring is recommended, along with drugs that may prolong the QT interval.Serious - Use Alternative (1)citalopram and erythromycin stearate both increase QTc interval. Monitor Closely (1)chlorpromazine and citalopram both increase QTc interval. ECG monitoring is recommended if coadministered. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. If possible, avoid concurrent use. Initial: 10 mg orally once/day; may titrate to 40 mg/day. Either increases toxicity of the other by sedation. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. mirabegron will increase the level or effect of citalopram by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (1)idelalisib will increase the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. citalopram increases effects of antithrombin III by pharmacodynamic synergism. Monitor Closely (1)romidepsin and citalopram both increase QTc interval. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. Contraindicated (1)tranylcypromine and citalopram both increase serotonin levels. In vitro studies suggest that lumacaftor may induce and ivacaftor may inhibit CYP2C19 substrates. Fexinidazole inhibits CYP3A4. citalopram and lithium both increase QTc interval. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents. Possible additive hyponatremia. Monitor Closely (1)citalopram and dasatinib both increase QTc interval. Avoid coadministration of abiraterone with substrates of CYP2D6. Use Caution/Monitor. Monitor Closely (1)citalopram, tolmetin. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. If possible, avoid concurrent use. If possible, avoid concurrent use. Avoid or Use Alternate Drug. Increased risk of upper GI bleeding. Monitor Closely (1)isradipine and citalopram both increase QTc interval. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. Increased risk of serotonin syndrome or neuroleptic malignant syndrome. Avoid or Use Alternate Drug. Combination may increase risk of serotonin syndrome or neuroleptic malignant syndrome-like reactions.Serious - Use Alternative (1)morphine, citalopram. Discontinue buprenorphine if serotonin syndrome is suspected.Serious - Use Alternative (1)buprenorphine subdermal implant and citalopram both increase QTc interval. serotonin uptake by platelets. ceritinib and citalopram both increase QTc interval. Avoid or Use Alternate Drug. Monitor Closely (2)citalopram, lisdexamfetamine. Report any new or worsening symptoms right away.It may take 1 to 4 weeks to feel a benefit from this drug and up to several weeks before you get the full benefit.Tell your doctor if your condition does not improve or if it worsens. Use Caution/Monitor. Elagolix is a weak CYP2C19 inhibitor. Monitor Closely (1)methamphetamine, citalopram. If not feasible, avoid use of abametapir. Methylene blue may increase serotonin as a result of MAO-A inhibition. Combination may increase risk of serotonin syndrome. Use Caution/Monitor. Increased risk of upper GI bleeding. Serious - Use Alternative (1)fentanyl transdermal, citalopram. Use Caution/Monitor. etravirine will decrease the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (2)efavirenz will decrease the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Risk of serotonin syndrome.citalopram, lisdexamfetamine. Monitor Closely (1)oxycodone increases effects of citalopram by pharmacodynamic synergism. Monitor Closely (1)gemifloxacin and citalopram both increase QTc interval. Either increases effects of the other by serotonin levels. Use lowest dose possible and monitor for respiratory depression and sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. Either increases effects of the other by serotonin levels. Either increases toxicity of the other by pharmacodynamic synergism. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions. Monitor Closely (1)citalopram, zanubrutinib. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. This medication works by helping to restore the balance of a certain natural substance (serotonin) in the brain. Monitor Closely (1)rifabutin will decrease the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potential risk for QT prolongation. Risk of serotonin syndrome. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. ECG monitoring is recommended, along with drugs that may prolong the QT interval. octreotide and citalopram both increase QTc interval. Monitor Closely (1)bosentan will decrease the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Combination may increase risk of bleeding. Either increases toxicity of the other by pharmacodynamic synergism. Serious - Use Alternative (2)gilteritinib will decrease the level or effect of citalopram by Other (see comment). Contraindicated. Concurrent use of dronedarone with other agents that can prolong QT interval is contraindicated. Potential for increased toxicity. Either increases toxicity of the other by serotonin levels. Treatment withdrawal: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Either increases effects of the other by Mechanism: pharmacodynamic synergism. amiodarone and citalopram both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. pharmacodynamic synergism. Modify Therapy/Monitor Closely. iloperidone and citalopram both increase QTc interval. By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. Monitor Closely (1)osilodrostat and citalopram both increase QTc interval. Monitor Closely (1)lorcaserin will increase the level or effect of citalopram by affecting hepatic enzyme CYP2D6 metabolism. Your doctor may adjust your dose as needed. Monitor Closely (1)isoniazid will increase the level or effect of citalopram by affecting hepatic enzyme CYP2C19 metabolism. Its recommended to start with a lower dose before switching to the capsule. citalopram and olanzapine both increase QTc interval. ECG monitoring is recommended, along with drugs that may prolong the QT interval. Use Caution/Monitor. If unable to avoid concomitant use, obtain ECGs and electrolytes before and after initiation of any drug known to prolong QTc, and periodically monitor as clinically indicated during treatment. citalopram and amitriptyline both increase serotonin levels. Monitor Closely (1)sufentanil SL, citalopram. Contraindicated (1)leuprolide increases toxicity of citalopram by QTc interval. Use Caution/Monitor. Monitor Closely (1)pazopanib and citalopram both increase QTc interval. Avoid or Use Alternate Drug. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. commonly, these are generic drugs. Other (see comment). Most clinically significant changes occur . citalopram and perphenazine both increase QTc interval. Use Caution/Monitor. citalopram and salmeterol both increase QTc interval. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. View the formulary and any restrictions for each plan. Your doctor will prescribe the maintenance dosage that's right for you. Coadministration of zanubritinib with antiplatelets or anticoagulants may further increase this risk. dichlorphenamide and citalopram both decrease serum potassium. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. Serious - Use Alternative (1)citalopram and olopatadine intranasal both increase sedation. citalopram and lorcaserin both increase serotonin levels. Avoid or Use Alternate Drug. ECG monitoring is recommended, along with drugs that may prolong the QT interval. lapatinib and citalopram both increase QTc interval. Serious - Use Alternative (1)citalopram and entrectinib both increase QTc interval. Follow your doctor's orders or the directions on the label. Avoid or Use Alternate Drug. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Contraindicated. Possible additive hyponatremia.indapamide and citalopram both increase QTc interval. doxepin and citalopram both increase QTc interval. Serious - Use Alternative (2)lonafarnib will increase the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)citalopram, diflunisal. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Potential risk for QT prolongation. Use Caution/Monitor. ozanimod and citalopram both increase QTc interval. Serious - Use Alternative (1)citalopram and venlafaxine both increase serotonin levels. Please seek medical advice before starting, changing or terminating any medical treatment. SSRIs vs SNRIs - What's the difference between them? Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval.Serious - Use Alternative (1)citalopram and oxaliplatin both increase QTc interval. Monitor for adverse effects if coadministered with sensitive substrates of these enzymes.tecovirimat will decrease the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Possible additive hyponatremia. Monitor Closely (1)citalopram increases effects of heparin by pharmacodynamic synergism. Combination may increase risk of serotonin syndrome. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Combinatiomay increase risk of serotonin syndrome or neuroleptic malignant syndromn e like reactions. If possible, avoid concurrent use. Avoid or Use Alternate Drug. Continuously monitor vital signs during sedation and recovery period if coadministered. Avoid or Use Alternate Drug. Use Caution/Monitor. citalopram and 5-HTP both increase serotonin levels. Use alternatives if available. This document does not contain all possible drug interactions. citalopram and panobinostat both increase QTc interval. Use Caution/Monitor. Coadministration with drugs that lower seizure threshold may increase this risk. Use Caution/Monitor. Use Caution/Monitor. Combination may increase risk of serotonin syndrome or neuroleptic malignant syndrome-like reactions. bosentan will decrease the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)citalopram, buprenorphine subdermal implant. Increased risk of upper GI bleeding. citalopram and ganaxolone both increase sedation. Mechanism: unknown. Use Caution/Monitor. cobicistat will increase the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Citalopram may increase TCA levels. This could result in serotonin syndrome. Either increases toxicity of the other by serotonin levels. erythromycin lactobionate increases levels of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. SIDE EFFECTS: See also Warning and Precautions sections.Nausea, dry mouth, loss of appetite, tiredness, drowsiness, sweating, blurred vision, and yawning may occur. These symptoms will usually go away after a couple of weeks or once you start taking Celexa again. QTc interval. Either increases toxicity of the other by pharmacodynamic synergism. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. citalopram and duloxetine both increase serotonin levels. Avoid or Use Alternate Drug. If serotonin syndrome occurs, discontinue along with concomitant serotonergic drug(s). Increased risk of upper GI bleeding. Combination may increase risk of bleeding. Use Caution/Monitor. Minor/Significance Unknown. Increased risk of upper GI bleeding. Use Caution/Monitor. Contraindicated. gilteritinib will decrease the level or effect of citalopram by Other (see comment). Avoid or Use Alternate Drug. Your doctor may adjust your dose as needed. Use Caution/Monitor. This isnt a complete list of interacting medications that may need a lower dose of Celexa. ECG monitoring is recommended, along with drugs that may prolong the QT interval. Use Caution/Monitor. citalopram and nefazodone both increase serotonin levels. citalopram and erythromycin ethylsuccinate both increase QTc interval. Monitor Closely (1)degarelix and citalopram both increase QTc interval. US residents can call their local poison control center at 1-800-222-1222. citalopram and siponimod both increase QTc interval. Monitor Closely (1)methylphenidate transdermal will increase the level or effect of citalopram by decreasing metabolism. Avoid or Use Alternate Drug. Too much Celexa can also cause a dangerous heart condition called long QT syndrome, which can be fatal if not treated right away. Use Caution/Monitor. CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of citalopram by affecting hepatic enzyme CYP2D6 metabolism. You can unsubscribe at any time. citalopram and sevoflurane both increase QTc interval. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. conivaptan increases levels of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. citalopram, eletriptan. ECG monitoring is recommended, along with drugs that may prolong the QT interval. Serious - Use Alternative (1)citalopram increases toxicity of umeclidinium bromide/vilanterol inhaled by QTc interval. citalopram, naproxen. ECG monitoring is recommended, along with drugs that may prolong the QT interval. Monitor Closely (1)ozanimod and citalopram both increase QTc interval. Other (see comment). The typical Celexa dosage for adults starts at 20 mg by mouth once daily. Use Caution/Monitor. Monitor Closely (1)toremifene and citalopram both increase QTc interval. Risk of GI adverse effects may be increased. Use Caution/Monitor. Increased risk of upper GI bleeding. Either increases effects of the other by serotonin levels. citalopram and ondansetron both increase QTc interval. Although citalopram is a weak inhibitor of 2D6, the potential for an interaction exists.atomoxetine and citalopram both increase QTc interval. lamotrigine increases toxicity of citalopram by unspecified interaction mechanism. The maximum recommended dose of Celexa in people with liver impairment is 20 mg/day. citalopram, vandetanib. Serious - Use Alternative (2)citalopram and nortriptyline both increase serotonin levels. Possible additive hyponatremia. Avoid or Use Alternate Drug. Monitor Closely (2)indapamide and citalopram both increase QTc interval. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Maintenance dosage range: Celexa's maintenance dosage ranges from 20 mg to 40 mg once per day. At least 2 weeks should elapse between discontinuation of MAOI therapy and the start of citalopram therapy, and at least 2 weeks between discontinuation of citalopram therapy and commencement of MAOI therapy. Use Caution/Monitor. Avoid or Use Alternate Drug. fedratinib will increase the level or effect of citalopram by affecting hepatic enzyme CYP2C19 metabolism. Either increases toxicity of the other by pharmacodynamic synergism. If possible, avoid concurrent use. Use Caution/Monitor. citalopram increases toxicity of umeclidinium bromide/vilanterol inhaled by QTc interval. commonly, these are "non-preferred" brand drugs or specialty posaconazole will increase the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)voclosporin, citalopram. Use Caution/Monitor. Your healthcare provider will help figure out the best way to adjust your Celexa dosage based on your response. ECG monitoring is recommended, along with drugs that may prolong the QT interval. SSRIs may inhibit platelet aggregation, thus increase bleeding risk when coadministered with anticoagulants. Use Caution/Monitor. secobarbital will decrease the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Increased risk of upper GI bleeding. Ask your pharmacist about using those products safely.Many drugs besides citalopram may affect the heart rhythm (QT prolongation), including amiodarone, pimozide, procainamide, quinidine, sotalol, among others.Citalopram is very similar to escitalopram. Recent studies have found a citalopram dose of 10 mg to work in some people for treating depression. Use Caution/Monitor. Serious - Use Alternative (1)citalopram and pitolisant both increase QTc interval. Use Caution/Monitor. droperidol and citalopram both increase QTc interval. ECG monitoring is recommended, along with drugs that may prolong the QT interval. citalopram, sulindac. Monitor Closely (1)citalopram, sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol. Linezolid may increase serotonin as a result of MAO-A inhibition. Use Caution/Monitor. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and opioid pain relievers (such as codeine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. SSRIs affect platelet activation; coadministration of SSRIs with clopidogrel may increase the risk of bleeding. ECG monitoring is recommended, along with drugs that may prolong the QT interval. But if you have concerns about your Celexa dosage at any time, reach out to your healthcare provider. Most Minor/Significance Unknown. ECG monitoring is recommended, along with drugs that may prolong the QT interval. citalopram, ibuprofen. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT. Avoid with drugs known to prolong QT interval. SSRIs and SNRIs may increase anticoagulation effect of warfarin. Monitor Closely (1)ethacrynic acid, citalopram. Avoid or Use Alternate Drug. citalopram, celecoxib. Serious - Use Alternative (2)ribociclib will increase the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. selinexor, citalopram. Monitor Closely (1)midazolam intranasal, citalopram. Citalopram may increase TCA levels. Increased risk of upper GI bleeding. Adjust dose according to prescribing information if needed. Ask your doctor or pharmacist for more details.Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Monitor Closely (1)fluvoxamine will increase the level or effect of citalopram by affecting hepatic enzyme CYP2C19 metabolism. Increased risk of upper GI bleeding. Monitor Closely (1)citalopram, vorapaxar. Use Caution/Monitor. Contraindicated. Avoid or Use Alternate Drug. If concomitant treatment with citalopram and a triptan is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases. tranylcypromine and citalopram both increase serotonin levels. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. ECG monitoring is recommended. Avoid or Use Alternate Drug. Mechanism: pharmacodynamic synergism. Possible additive hyponatremia. Monitor Closely (1)erythromycin base increases levels of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first. How quickly can acute migraines be treated? Consider increasing CYP3A substrate dose if needed. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (1)nefazodone increases levels of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. Either increases toxicity of the other by serotonin levels. ECG monitoring is recommended, along with drugs that may prolong the QT interval. Potential risk for QT prolongation. If coadministration unavoidable, monitor for adverse reactions and reduce the CYP2C19 substrate dose in accordance with its approved product labeling. fish oil triglycerides will increase the level or effect of citalopram by anticoagulation. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity. Avoid or Use Alternate Drug. ECG monitoring is recommended, along with drugs that may prolong the QT interval. Use Caution/Monitor. citalopram and clomipramine both increase serotonin levels. Monitor Closely (1)mirabegron will increase the level or effect of citalopram by affecting hepatic enzyme CYP2D6 metabolism. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Monitor Closely (1)crizotinib increases levels of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Possible additive hyponatremia. Use Caution/Monitor. At least 2 weeks should elapse between discontinuation of MAOI therapy and the start of citalopram therapy, and at least 2 weeks between discontinuation of citalopram therapy and commencement of MAOI therapy. Use Caution/Monitor. Use Caution/Monitor. ECG monitoring is recommended, along with drugs that may prolong the QT interval. Additive effects; increased risk for serotonin syndrome, neuroleptic malignant syndrome, dystonia, or other extrapyramidal reactions. Serious - Use Alternative (1)methylene blue and citalopram both increase serotonin levels. Use Caution/Monitor. Potential risk for QT prolongation. elagolix will increase the level or effect of citalopram by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. Use Caution/Monitor. If possible, avoid concurrent use. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. abametapir will increase the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. citalopram, oliceridine. dacomitinib will increase the level or effect of citalopram by affecting hepatic enzyme CYP2D6 metabolism. Possible additive hyponatremia. Monitor Closely (2)elagolix will increase the level or effect of citalopram by affecting hepatic enzyme CYP2C19 metabolism. methyclothiazide, citalopram. both increase serotonin levels; increased risk of serotonin syndrome. pharmacodynamic synergism. Either increases effects of the other by anticoagulation. If not feasible, avoid use of abametapir. Mechanism: unknown. Use Caution/Monitor. Monitor Closely (1)ticlopidine increases levels of citalopram by affecting hepatic enzyme CYP2C19 metabolism. Prolonged bleeding reported in patients taking antiplatelet agents or anticoagulants and oral omega-3 fatty acids. Combination may increase risk of serotonin syndrome or neuroleptic malignant syndrome-like reactions. Either increases toxicity of the other by serotonin levels. If concomitant treatment with citalopram and a triptan is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases. Modify Therapy/Monitor Closely. Monitor Closely (1)citalopram, meclofenamate. Serious - Use Alternative (2)citalopram and protriptyline both increase serotonin levels. Consider dose reduction of sensitive CYP3A4 substrates. Use Caution/Monitor. If intolerable symptoms occur, it is recommended to consider resuming the previously prescribed dose and to decrease the dose at a more gradual rate. istradefylline will increase the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)dexmethylphenidate increases effects of citalopram by decreasing metabolism. Avoid or Use Alternate Drug. fluvoxamine will increase the level or effect of citalopram by affecting hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Either increases toxicity of the other by pharmacodynamic synergism. Six patients (8.2%) among the entire study . Use Caution/Monitor. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Carefully titrate dose of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitor its response during coadministration with SSRIs and cobicistat. primidone will decrease the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)citalopram and tapentadol both increase serotonin levels. nelfinavir increases levels of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Continuously monitor vital signs during sedation and recovery period if coadministered. Color: pink Shape: round . Information last revised December 2022. Increased risk of upper GI bleeding. Avoid or Use Alternate Drug. methylphenidate transdermal will increase the level or effect of citalopram by decreasing metabolism. furosemide, citalopram. Combination may increase risk of serotonin syndrome. Always ask your health care professional for complete information about this product and your specific health needs. tazemetostat will decrease the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Monitor Closely (1)citalopram and morphine both increase serotonin levels. Combination may increase risk of serotonin syndrome or neuroleptic malignant syndrome-like reactions. Use Caution/Monitor. You are being redirected to If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling. Use Caution/Monitor. Monitor for antidepressant response. Avoid or Use Alternate Drug. Your condition will not improve any faster, and your risk of side effects will increase. Coadministration of zanubritinib with antiplatelets or anticoagulants may further increase this risk. Citalopram may increase TCA levels. Avoid or Use Alternate Drug. If serotonin syndrome occurs, discontinue dextroamphetamine transdermal and concomitant serotonergic drug(s). Dr. Pamela Pappas answered Psychiatry 44 years experience Variable: Citalopram dose might start at 10mg, and be titrated to 20-40mg/day. Avoid or Use Alternate Drug. Contraindicated. Potential risk for QT prolongation. citalopram and SAMe both increase serotonin levels. Use Caution/Monitor. unspecified interaction mechanism. Increased risk of serotonin syndrome or neuroleptic malignant syndrome. ECG should be monitored closely. citalopram and L-tryptophan both increase serotonin levels. Celexa (citalopram) should be administered at an initial dose of 20 mg once daily, with an increase to a maximum dose of 40 mg/day at an interval of no less than one week. Avoid or Use Alternate Drug. paliperidone and citalopram both increase QTc interval. citalopram and dihydroergotamine intranasal both increase serotonin levels. CeleXA; Descriptions. Monitor Closely (1)istradefylline will increase the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If concomitant treatment with citalopram and a triptan is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases. ECG monitoring is recommended, along with drugs that may prolong the QT interval.iloperidone increases levels of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Recommended dose: 20 mg orally once a day They may also be more likely to develop a type of salt imbalance (hyponatremia), especially if they are also taking "water pills" (diuretics). Use Caution/Monitor. Contraindicated. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Now, youll enjoy a streamlined experience created specifically for healthcare providers. Acute episodes of depression may require several months or more of sustained pharmacologic therapy. Modify Therapy/Monitor Closely. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmias. Monitor Closely (1)ezogabine, citalopram. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.ondansetron, citalopram. Either increases effects of the other by anticoagulation. . Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. Increases risk of torsades de pointes. ribociclib and citalopram both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug. Monitor Closely (1)citalopram, piroxicam. Use Caution/Monitor. Monitor Closely (1)selpercatinib increases toxicity of citalopram by QTc interval. Modify Therapy/Monitor Closely. Mechanism: unknown. Monitor Closely (1)citalopram will increase the level or effect of tizanidine by Other (see comment). citalopram and fluconazole both increase QTc interval. Either increases toxicity of the other by pharmacodynamic synergism. sodium sulfate/?magnesium sulfate/potassium chloride increases effects of citalopram by unknown mechanism. Avoid or Use Alternate Drug. Use Caution/Monitor. Otherwise, call a poison control center right away. Use Caution/Monitor. Carefully titrate dose of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitor its response during coadministration with SSRIs and cobicistat. Either increases effects of the other by serotonin levels. Either increases toxicity of the other by serotonin levels. Increased risk of upper GI bleeding. Avoid or Use Alternate Drug. ECG monitoring is recommended, along with drugs that may prolong the QT interval. Monitor Closely (1)citalopram increases effects of metformin by pharmacodynamic synergism. ECG monitoring is recommended, along with drugs that may prolong the QT interval. Monitor Closely (1)citalopram will increase the level or effect of risperidone by affecting hepatic enzyme CYP2D6 metabolism. Families and caregivers should be advised of the need for close observation and communication with the prescriber. After at least a week, your healthcare provider may raise your dose to 40 mg once daily. Use Caution/Monitor. ECG monitoring is recommended, along with drugs that may prolong the QT interval. Avoid or Use Alternate Drug. midazolam intranasal, citalopram. Monitor Closely (1)ibrutinib will increase the level or effect of citalopram by anticoagulation. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmias. Contraindicated. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered. gabapentin, citalopram. GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Serious - Use Alternative (1)citalopram and glasdegib both increase QTc interval. What is the difference between Celexa and Lexapro? Use Caution/Monitor. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Be sure to read on for. Modify Therapy/Monitor Closely. citalopram and maprotiline both increase QTc interval. Serious - Use Alternative (1)citalopram and primaquine both increase QTc interval. All rights reserved. Increased risk of upper GI bleeding. Last updated on Nov 9, 2021. Possible additive hyponatremia. Coadministration with SSRIs, TCAs, or trazodone may require dose titration of antidepressant to desired effect (eg, using the lowest feasible initial or maintenance dose). ECG monitoring is recommended, along with drugs that may prolong the QT interval. Use Caution/Monitor. Avoid or Use Alternate Drug. dronedarone and citalopram both increase QTc interval. Lithium may enhance the serotonergic effects of citalopram, caution should be exercised when citalopram and lithium are coadministered.Serious - Use Alternative (1)citalopram and lithium both increase QTc interval. Monitor Closely (1)posaconazole will increase the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)citalopram and salmeterol both increase QTc interval. Either increases toxicity of the other by QTc interval. Combination may increase risk of bleeding. Combination may increase risk of serotonin syndrome or neuroleptic malignant syndrome-like reactions.Serious - Use Alternative (1)meperidine, citalopram. Use Caution/Monitor. citalopram 20 mg tablet. Use Caution/Monitor. granisetron, citalopram. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. Serious - Use Alternative (1)citalopram and pimavanserin both increase QTc interval. Use Caution/Monitor. If possible, avoid concurrent use. Last updated on Nov 9, 2021. Use Caution/Monitor. Increased risk of upper GI bleeding. Comments: Over 60 years of age: citalopram, meclofenamate. Monitor Closely (1)citalopram, oliceridine. citalopram, naratriptan. leuprolide increases toxicity of citalopram by QTc interval. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and reduces efficacy related to these substrates. Citalopram may increase TCA levels. SUMMARY: The Food and Drug Administration (FDA or Agency) is announcing the availability of the final decision withdrawing approval of MAKENA (hydroxyprogesterone caproate injection, 250 milligrams (mg) per milliliter (mL), once weekly), under the new drug application (NDA) 021945, held by Covis Pharma Group/Covis Pharma . Monitor Closely (1)lorlatinib will decrease the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Increased metoprolol plasma levels have been associated with decreased cardioselectivity. The average household teaspoon may not hold the right amount of liquid. Monitor Closely (1)cannabidiol will increase the level or effect of citalopram by affecting hepatic enzyme CYP2C19 metabolism. (2023). Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Monitor Closely (1)esomeprazole will increase the level or effect of citalopram by affecting hepatic enzyme CYP2C19 metabolism. Comment: Combination may increase risk of bleeding. Use Caution/Monitor. Minor (1)acetazolamide will increase the level or effect of citalopram by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ECG monitoring is recommended, along with drugs that may prolong the QT interval.Serious - Use Alternative (1)citalopram and cyclobenzaprine both increase serotonin levels. Use Caution/Monitor. Mechanism: unknown. Serious - Use Alternative (1)citalopram, eletriptan. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. Use Caution/Monitor. Combination may increase risk of serotonin syndrome. ECG monitoring is recommended, along with drugs that may prolong the QT interval. Monitor Closely (3)cenobamate, citalopram. Use Caution/Monitor. citalopram and morphine both increase serotonin levels. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. ECG monitoring is recommended, along with drugs that may prolong the QT interval. Modify Therapy/Monitor Closely. Combination may increase risk of serotonin syndrome or neuroleptic malignant syndrome-like reactions. Monitor Closely (1)gabapentin, citalopram. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.This drug passes into breast milk and may have undesirable effects on a nursing infant. citalopram and promethazine both increase serotonin levels. vemurafenib and citalopram both increase QTc interval. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride increases effects of citalopram by unknown mechanism. Use Caution/Monitor. But if youre over the age of 60 or have a history of liver damage, doses over 20 mg per day arent recommended. ECG monitoring is recommended, along with drugs that may prolong the QT interval. Serious - Use Alternative (1)citalopram, sumatriptan intranasal. Serious - Use Alternative (1)desflurane and citalopram both increase QTc interval. Your Celexa dosage at any time, reach out to your personal circumstances umeclidinium. The cardiovascular system ; increased risk of side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - call doctor... As indicated, or other extrapyramidal reactions FDA at 1-800-FDA-1088 or at Canada! Citalopram to prevent panic attacks, your healthcare provider will help figure out the best way adjust. An interaction exists.atomoxetine and citalopram both increase QTc interval streamlined experience created specifically for healthcare providers decreased! Clear vision until you can do it safely have found a citalopram dose might start at 10mg, and receive., moisture, and to receive marketing messages from GoodRx beta2 agonists on cardiovascular. At any time, reach out to your healthcare provider carefully observe the patient, during... The typical Celexa dosage for adults starts at 20 mg per day increased the risk of effects! Until you can do it safely redirected to if unavoidable, decrease the level or effect citalopram... 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